Western University, Canada - London Ontario

| Monday September 26, 2016
11:33 PM

Neurology - Area of Focus

Academic Appointment

Professor of Neurology and Epidemiology, Western University; Distinguished University Professor

Bio Sketch

 NEUROLOGY – AREAS OF FOCUS

Cerebrovascular and Dementia

Stroke, Preventable Dementias, World Neurology

 BIO SKETCH
Dr. Vladimir Hachinski received his MD from the University of Toronto. After completing his residency training at the same university, he undertook a Cerebrovascular Laboratory fellowship at the National Hospital for Nervous Diseases at Queen Square in London, England with Professor John Marshall and a research fellowship at the Department of Clinical Physiology with Professor Niels Lassen, Bispebjerg Hospital in Copenhagen, Denmark.

Dr. Hachinski is Professor of Neurology and Distinguished University Professor at Western University, He founded, with John W. Norris the first successful acute stroke unit which has become the standard of care and with David Cechetto discovered the key role of the insula of the brain in mediating cardiac arrhythmias and sudden death. He introduced the concepts and terms multi-infarct dementia, leukoaraiosism, brain and risk stage and vascular cognitive impairment and devised the Hachinski ischemic score, the standard for identifying a vascular (treatable) component of cognitive impairment. (over 2300 citations)

Dr. Hachinski was Editor-in-Chief of the journal Stroke, the leading publication in the field for an unprecedented 10 year term from 2000-2010. He introduced 9 international editions and a unique author mentorship program. He has contributed over 800 scientific papers, book chapters, editorials and other scholarly publications, with over 31,000 citations and an H-Index of 83. He is the author, co-author or editor or co-editor of 17 books including Stroke: A Comprehensive Guide to Brain Attack, co-authored with his daughter Larissa Hachinski, written to increase public awareness of brain attack, a term coined by Dr. Hachinski to help drive home the urgency of strokes.

He has received 4 honorary doctorates, the Mihara International Award, World Stroke Organization Leadership in Stroke Medicine Award, the Premier's Discovery Award in the Life Sciences and Medicine for "ground breaking research on relationship between stroke and Alzheimer disease". Dr. Hachinski was the founding Chair of the International Society for Vascular Behavioural and Cognitive Disorders, past Vice President of the World Stroke Organization, President of the World Federation of Neurology, 2010-2013 and Founding Chair World Brain Alliance (comprising the major world brain organizations). He is Vice President of the World Stroke Organization. He was awarded the 2011 International BIAL Merit Award in Medical Sciences for a monograph on "The Long Fuse: Silent Strokes and Insidious Alzheimer Disease" and in 2012 a Doctor honoris causa from the Russian Academy of Medical Sciences. In 2008 he received the Order of Canada and in 2013 the Order of Ontario and the Queen Elizabeth II Diamond Jubilee Medal. He was the 2013 Paddison Lecturer and was awarded the Chancellor's Award Lecture in Neuroscience and Neurology for his "contributions to neurological sciences and for outstanding academic leadership" at the University of Louisiana. Dr. Hachinski was the Allan & Maria Myers International Visiting Fellow for 2014 at the Florey Institute in Melbourne, Australia and was the 2014 Brain Scholar, Cambridge, Oxford and London UK Universities.  In 2014 he was elected member of the Royal Society of Canada.

Research

Dr. Hachinski connects, coordinates and synergizes groups involved in experimental, clinical and population studies in the prevention of stroke and dementia.

Experimental
With David F. Cechetto and Shawn Whitehead of Western's Department of Anatomy and Cell Biology, he observed in Alzheimer animal models that the presence of the protein amyloid is associated with inflammation and brain damage when a stroke is induced and that this can be prevented with anti-inflammatory drugs. Alexander Thiel (Montreal) has begun studies in patients to confirm their experimental findings.

Collaborators: Shawn Whitehead and David Chechetto

Students: Aaron Regis, PhD, Co-supervised with Shawn Whitehead

Alex Levit, MD PhD, Co-supervised with Shawn Whitehead

Nina Weishaupt, PhD, post doctoral student, Co-supervised with Shawn Whitehead


Clinical Trials

The PARTNERS Study

He is co-principal investigator of a Canada wide CIHR funded multi-center study led by Richard Chan, using trained volunteers to work with high-risk patients for better control of blood pressure and other vascular risk factors to prevent stroke and cognitive decline.


Population

Executive dysfunction as an early warning system of stroke and preventable cognitive decline.
Collaborators: Miia Kivipelto, Karolinska Institute, Stockholm, Sweden; David Bennett, Julie Schneifer, Rush University, Chicago.Research Fellow: Shahram Oveisgharan

Preventing dementia by preventing stroke

Collaborators: Luciano A Sposato, Western University, Lauren Cipriano, Ivey Business School, Moira kapral, University of Toronto, Jiming Fang, Institute for Clinical Evaluative Sciences, Sudeep Gill, Queen's University, Hadas Fischer, Institute for Clinical Evaluative Sciences.  PhD student: Joshua Cerasuolo

Hachinski Ischemic Score as an identifier of pure Alzheimer disease

Collaborators: Suzanne Tyas, University of Waterloo, David Munoz, University of Toronto.  Clinical Fellow: Reza Azarpazhooh

Neuroscience

Handedness and brain patterns of cardiovascular control
Collaborators: Kevin Shoemaker, David Cechetto, Seyed Mirsattari, Peter Leung-Sit, AnthonyTang, David Ramsay, Mark Daley, Elizabeth Hanpson, Western University.  Neurology resident: Alex Melinysyn

RESEARCH OPPORTUNITIES

1. Research projects for residents and postgraduate students of neurology and epidemiology.

2. Fellowships for those who have completed their training.

3. Visting scholarships

Please contact:

 

Vladimir Hachinski

Medical Interests

  • Clinical Trials
  • Dementia
  • Alzheimer's Disease
  • Cerebrovascular Diseases
  • Stroke Prevention
  • Stroke

Office Contact Information

  • Phone:519 - 663 - 3624
  • Fax:519 - 663 - 3910
  • Address:

London Health Sciences Centre
University Hospital
339 Windermere Road
London Ontario Canada
N6A 5A5

Clinic Information:

Urgent TIA Clinic - UH 7-OPD

Tuesday 1:00 to 4:30pm; Thursday 9:00am to 4:30pm

Referral Contact: 519-663-3674; Fax 519-663-3140

ONLY sees patients referred to the stroke prevention clinic.

Office Hours: Monday to Friday 8:30am to 4:30pm

Administrative Assistant: Rebecca Clarke

E-mail: rebecca.clarke@lhsc.on.ca