Western University, Canada - London Ontario

| Tuesday September 2, 2014
5:13 PM

Academic Appointment

Assistant Professor of Neurology, Western University and Associate Scientist, Molecular Brain Research Group, Robarts Research Institute

Bio Sketch

Dr. Pasternak received his S. B. Degrees in Chemical Engineering and in Life Sciences from the Massachusetts Institute of Technology in Cambridge, Massachusetts. He completed the MD/PhD program at McGill University, Montreal, earning his PhD in the Department of Neurology and Neurosurgery in 1994 and his M.D. C.M. in 1995. Dr. Pasternak then completed his Neurology residency at the University of Toronto Fin 2000, followed by Post-Doctoral training in Cell Biology at the Hospital of Sick Children in Toronto and Fellowship training in Cognitive Neurology at the University of Toronto.

Research

Dr. Stephen Pasternak is a Neurologist specialized in the diagnosis and treatment of neurodegenerative disease and a basic scientist at the Robarts Research Institute at Western University. At his clinic in Cognitive Neurology and Alzheimer's Disease Research Unit at St. Joseph's Hospital he sees patients with neurodegenerative disease and participates in academic and industry sponsored clinical trials focused on diagnosing and treating neurodegenerative disease.

The Pasternak laboratory at the Robarts Research Institute at the University of Western Ontario is focused on understanding the basic cell biological changes in Alzheimer's disease, and detecting these changes using MRI imaging.  Alzheimer's disease is caused by a toxic protein called beta-amyloid which builds up in the brain. We have attached fluorescent protein tags to a number of proteins responsible for the production of beta-amyloid. This allows us to directly visualize these proteins in the microscope, studying their movement and interactions proteins in live cells using laser-scanning confocal microscopy. We are also working with Dr. Robert Bartha, an Imaging Scientist at the Robarts Research Institute, to design MRI techniques to detect the changes of Alzheimer's disease in the brain using very high field MRI. We hope that our work will lead to a better understanding of Alzheimer's disease which will lead to diagnosis and treatment of Alzheimer's disease.

Stephen H. Pasternak

Medical Interests

  • Clinical Trials
  • Alzheimer's Disease
  • Neurodegenerative Diseases
  • Behavioural Disorders
  • Cognitive Disorders
  • Magnetic Resonance Imaging (MRI)

Office Contact Information

  • Phone:519 - 646 - 6032
  • Address:

Cognitive Neurology and Alzheimer
St. Joseph's Hospital
268 Grosvenor Street
London Ontario Canada
N6A 4V2