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November 2009
Early monotherapy with rasagiline for symptomatic management of Parkinson's Disease was efficacious, but there was insufficient
evidence of neuroprotection.ID #153 | November 2009 | PDF DocumentSpecialty
: Movement Disorders | Category : Therapy- Early monotherapy with rasagiline was efficacious for symptomatic management of Parkinson's Disease, but there wasinsufficient evidence
ofneuroprotection.ID #169 | November 2009 | PDF DocumentSpecialty :
Movement Disorders | Category : Therapy
May 2007
- In an open-labeled trial, piracetam was effective and safe in reducing myoclonus, both as mono or add-on therapy, in patients with myoclonus.ID #155 | May 2007 | PDF Document
- ASA reduces the
incidence of stroke in women with no previous history of cardiovascular events.ID #131 | May 2007 | PDF DocumentSpecialty : Vascular/Stroke | Category : Therapy
February 2006
- The specificity and sensitivity of conventional testing, including the tilt table, for diagnosis of unexplained syncope was not possible to
determine.ID #124 | February 2006 | PDF DocumentSpecialty :
Other | Category : Diagnosis
- Combined superficial peroneal nerve and peroneus brevis biopsy is a specific and sensitive diagnostic tool in patients with clinically
suspected vasculitic neuropathy.ID #157 | February 2006 | PDF Document
May 2005
- Current evidence does not support aneurysm screening in first-degree relatives of patients with subarachnoid hemorrhage.ID #119 |
May 2005 | PDF DocumentSpecialty : Vascular/Stroke | Category :
Diagnosis
- In
suspected sporadic CJD, the diagnostic sensitivity and specificity of MRI was 67% and 93% respectively.ID #118 | May 2005 | PDF
DocumentSpecialty : Infection | Category :
Diagnosis
- In the treatment of neurogenic orthostatic hypotension, midodrine increased standing
systolic blood pressure and resulted in a small improvement in symptomatic scores. The clinical significance of this is uncertain.ID #121 | May
2005 | PDF DocumentSpecialties : Movement Disorders, Other | Category
: Therapy
- There was an
association between coffee consumption and the risk of developing Parkinson's disease.ID #120 | May 2005 | PDF DocumentSpecialty : Movement Disorders | Category :
Diagnosis
January 2005
- Large size, posterior location, and prior history of SAH from another aneurysm was associated with an increased five-year rupture
rate of unruptured intracranial aneurysms.ID #113 | January 2005 | PDF DocumentSpecialty : Vascular/Stroke | Categories : Diagnosis, Prognosis
- Treatment of recurrent glioblastoma multiforme with temozolomide was safe and improved the proportion of patients with
progression-free survival at 6 months, as compared to procarbazine.ID #114 | January 2005 | PDF DocumentSpecialty : Oncology | Categories : Prognosis, Therapy
November 2004
- Ropinirole was an effective treatment for restless leg syndrome (RLS), but the magnitude of the effect was uncertain.ID #110 |
November 2004 | PDF DocumentSpecialty : Movement Disorders | Category
: Therapy
- The McDonald's MRI criteria may be useful for the early diagnosis of MS in patients presenting with a clinically isolated neurological syndrome.ID #111 | November 2004 | PDF DocumentSpecialty : Demyelinating Disease
| Category : Diagnosis
July 2004
- In the short-term, IVIg treatment increased muscle strength and resulted in the subjective improvement of patients with multifocal motor neuropathy.ID #105 | July 2004 | PDF DocumentSpecialty : Neuromuscular |
Category : Therapy
- Induced hypothermia reduced neurological disability and death when initiated early after VF cardiac arrest.ID #106 | July 2004
| PDF DocumentSpecialty : Critical Care | Categories :
Prognosis, Therapy
April 2004
- At 3 months post-surgery, bilateral STN or GPi stimulation improved motor function in patients with advanced Parkinson's disease in the off
medication state.ID #103 | April 2004 | PDF DocumentSpecialty :
Movement Disorders | Category : Therapy
- In patients with atherothrombotic non-disabling stroke there was no reduction in mortality, MI or stroke
with the use of triple vitamin therapy; high dose folic acid, pyridoxine (B6), and cobalamin (B12).ID #102 | April 2004 | PDF
DocumentSpecialty : Vascular/Stroke | Category :
Therapy
January 2004
- Bed rest was no better than immediate mobilization to prevent post-lumbar puncture headache.ID #100 | January 2004 |
PDF DocumentSpecialty : Other | Category :
Therapy
- IV dexamethasone decreased the risk of hearing loss in children with bacterial meningitis. The evidence was less convincing for
decreasing unfavourable outcomes in adults.ID #99 | January 2004 | PDF DocumentSpecialty : Infection | Categories : Prognosis, Therapy
- Canalith
repositioning maneuvres shortened the duration of benign paroxysmal positional vertigo.ID #98 | January 2004 | PDF DocumentSpecialty : Other | Category : Therapy
October 2003
- In early Parkinson's disease, Coenzyme Q10 was safe and well tolerated. There was no significant trend towards slowing of disease progression.ID #95 | October 2003 | PDF DocumentSpecialty : Movement Disorders
| Category : Therapy
- Oral
contraceptives increased the risk of stroke 2.75-fold (95% CI, 2.24, 3.38). There was no significant increased risk among patients with migraine.ID #94
| October 2003 | PDF DocumentSpecialty : Vascular/Stroke | Category : Harm
June 2003
- Low quality evidence suggested that combined high-dose methotrexate and radiotherapy was the best treatment for primary CNS lymphoma.ID
#90 | June 2003 | PDF DocumentSpecialty : Oncology | Category : Therapy
- The evidence did not
support the use of HMG-CoA Reductase Inhibitors to prevent dementia.ID #91 | June 2003 | PDF DocumentSpecialty : Cognitive / Behavioural | Category : Therapy
April 2003
- All triptans were effective and well tolerated in
treatment of acute migraine. Compared with 100 mg sumatriptan, 12.5 mg rizatriptan and 80 mg eletriptan were slightly more efficacious; 12.5 mg almotriptan was similarly efficacious but better
tolerated.ID #88 | April 2003 | PDF DocumentSpecialty :
Headache | Category : Therapy
- Carbamazepine was effective in the short-term management of trigeminal neuralgia (NNT 2.6 vs.
placebo). No drugs have demonstrated superiority in monotherapy. Surgery has not been adequately evaluated.ID #89 | April 2003 | PDF
DocumentSpecialty : Headache | Category :
Therapy
February 2003
- Acyclovir was superior
to Vidarabine in the treatment of biopsy-proven HSV encephalitis.ID #86 | February 2003 | PDF DocumentSpecialty : Infection | Category : Therapy
- Interferons decreased the risk of exacerbations in Relapsing-Remitting Multiple Sclerosis for 2 years. Differing
efficacy between various preparations and administration protocols is questionable.ID #85 | February 2003 | PDF DocumentSpecialty : Demyelinating Disease | Categories : Prognosis,
Therapy
January 2003
- Mitoxantrone 12mg/m^2 may reduce progression of disability in SP MS. However, clinical significance is questionable.ID
#83 | January 2003 | PDF DocumentSpecialty : Demyelinating Disease | Categories : Prognosis, Therapy
- Weak evidence showed improved survival with the use of BiPAP in patients with respiratory insufficiency due to ALS.ID #84 | January
2003 | PDF DocumentSpecialty : Neuromuscular | Category :
Therapy
December 2002
- Five heterogeneous studies suggested that patients with MCI or similar conditions had an increased risk of progression to
Alzheimer's disease, ranging between 6% and 25% per year.ID #82 | December 2002 | PDF DocumentSpecialty : Cognitive / Behavioural | Category : Prognosis
- In healthy adults with suspected meningitis clinical features ruled out significant abnormalities on cranial CT. This clinical
decision rule about CT before LP has yet to be validated.ID #81 | December 2002 | PDF DocumentSpecialty : Infection | Category : Diagnosis
November 2002
- Excessive somnolence occurs in > 50% of patients with Parkinson's disease. However, less than 1% had sleep attacks without warning while
driving.ID #80 | November 2002 | PDF DocumentSpecialty : Movement
Disorders | Category : Diagnosis
- Poor quality evidence suggested that surgical decompression for life-threatening cerebral edema
following acute ischemic hemispheric stroke, reduced the risk of death or dependency compared to medical therapy.ID #79 | November 2002
| PDF DocumentSpecialties : Critical Care, Vascular/Stroke | Categories
: Prognosis, Therapy
March 2002
- In patients with temporal-lobe epilepsy, surgery was superior to prolonged medical therapy,
at one-year follow-up. The NNT to render patients free from all seizures was 3 and free of seizures impairing awareness was 2.ID #71 | March 2002
| PDF DocumentSpecialty : Epilepsy | Categories : Prognosis,
Therapy
- Rivastigmine (6-12 mg daily) produced clinical and behavioral improvement in patients with Lewy-body dementia and was relatively well tolerated.ID #70 | March 2002 | PDF DocumentSpecialty : Cognitive / Behavioural
| Categories : Prognosis, Therapy
February 2002
- Clopidogrel plus aspirin therapy for acute coronary
syndromes without ST-elevation modestly reduced the risk of myocardial infarction (NNT 40) and the composite outcome of cardiovascular death, non-fatal MI, stroke OR refractory ischemia (NNT
43).ID #68 | February 2002 | PDF DocumentSpecialties : Other,
Vascular/Stroke | Categories : Prognosis, Therapy
- Depressed elderly outpatients and inpatients improved in depression scores by treating with TCA's (NNT 4), and SSRI's (NNT 8).ID #69
| February 2002 | PDF DocumentSpecialty : Other | Category
: Therapy
November 2001
- Diagnostic testing for coagulopathies had a low yield in patients with ischemic stroke, except for Antiphospholipid Antibodies.ID
#65 | November 2001 | PDF DocumentSpecialty : Neuromuscular | Categories : Economic Analysis, Meta-Analysis, Therapy
- Vagus nerve stimulation was moderately effective in reducing medically refractory partial seizures in the short term.ID #64 |
November 2001 | PDF DocumentSpecialty : Epilepsy | Category :
Therapy
October 2001
- Although generalized non-convulsive status epilepticus was associated with higher mortality in elderly, ICU patients, the severity
of the underlying illness predicted the outcome.ID #61 | October 2001 | PDF DocumentSpecialty : Epilepsy | Category : Prognosis
- In patients with a first attack of unifocal or multifocal MS and a positive MRI, early Interferon delayed the development of a second attack
(Clinically Definite MS).ID #63 | October 2001 | PDF DocumentSpecialty
: Vascular/Stroke | Category : Therapy
- In patients with GBS, the following factors predicted poor outcome: inability to walk independently at 8 weeks, age >
50 years, preceding gastrointestinal illness, and MRC sum score <40.ID #62 | October 2001 | PDF DocumentSpecialty : Vascular/Stroke | Category :
Prognosis
July 2001
- In cerebral sinus thrombosis,
low molecular weight heparin therapy for 3 weeks and 3 months of oral anticoagulation demonstrated a non-significant trend towards benefit over placebo. No significant hemorrhages occurred in those
with preexisting hemorrhage.ID #58 | July 2001 | PDF DocumentSpecialty
: Vascular/Stroke | Categories : Prognosis, Therapy
- In patients with anoxic encephalopathy, absent SSEPs, absent pupil reflexes, or no response to pain at 72 hours, independently
predicted death or vegetative state with 100% specificity.ID #57 | July 2001 | PDF DocumentSpecialty : Critical Care | Categories : Diagnosis, Prognosis
February 2001
- Early interferon treatment delayed development of a
second neurological event (ie. clinically definite multiple sclerosis) in patients with one demyelinating neurological event and MRI lesions indicative of previous clinically silent demyelinating
events.ID #53 | February 2001 | PDF DocumentSpecialty :
Demyelinating Disease | Categories : Prognosis, Therapy
- Gabapentin may be helpful in the treatment of essential tremor.ID #51 | February 2001 | PDF DocumentSpecialty : Movement Disorders
| Category : Therapy
- No valid evidence to
support any treatment for idiopathic intracranial hypertension.ID #52 | February 2001 | PDF DocumentSpecialties : Headache, Other | Category : Therapy
November 2000
- Donepezil (Aricept) slowed the progression of Alzheimer's disease up to one year, but the clinical significance is questionable.ID
#49 | November 2000 | PDF DocumentSpecialty : Cognitive / Behavioural |
Categories : Prognosis, Therapy
- The combination of dipyridamole and aspirin was more efficacious than aspirin alone in the secondary prevention of stroke.ID #47 |
November 2000 | PDF DocumentSpecialty : Vascular/Stroke | Categories
: Prognosis, Therapy
- The utilization of a graduated compression device (TED stockings) in addition to another prophylactic method prevented DVTs.ID #48
| November 2000 | PDF DocumentSpecialty : Other | Category
: Therapy
October 2000
- In the treatment of status epilepticus, there was no significant difference in outcomes with lorazepam, diazepam plus phenytoin, or phenobarbital.ID #46 | October 2000 | PDF DocumentSpecialty : Vascular/Stroke
| Category : Therapy
- No individual physical
examination finding was predictive of carpal tunnel syndrome.ID #45 | October 2000 | PDF DocumentSpecialties : Neurological Exam, Neuromuscular | Category : Diagnosis
August 2000
- Thrombolysis reduced overall death and dependency rate in
acute ischemic stroke. Intravenous t-PA demonstrated largest benefit with least hazard. However, thrombolysis also increased mortality in first 7-10 days, as well as intracranial
hemorrhages.ID #43 | August 2000 | PDF DocumentSpecialty :
Vascular/Stroke | Category : Therapy
- Portable
bladder ultrasound was a highly sensitive and specific tool to determine bladder volume.ID #42 | August 2000 | PDF DocumentSpecialties : Neuromuscular, Other | Category :
Diagnosis
April 2000
- Modafinil was safe and reduces excessive daytime sleepiness in narcoleptic patients, although the benefits are small.ID #37 | April
2000 | PDF DocumentSpecialty : Sleep Disorders | Category :
Therapy
- The overall risk of neurological sequella following a coronary artery bypass graft surgery (CABG) in the
immediate post operative period was 6.1%. The risk increases with increased associated risk factors.ID #38 | April 2000 | PDF
DocumentSpecialties : Other, Vascular/Stroke | Category :
Prognosis
February 2000
- In people with proven SAH on CT or LP, MRA detected an aneurysm with a sensitivity of 92% and specificity of 98%.ID #34 | February
2000 | PDF DocumentSpecialty : Vascular/Stroke | Category :
Diagnosis
- There was no difference in efficacy and tolerability between Lamotrigine and Carbamazepine in newly diagnosed partial or generalized epilepsy.ID #35 | February 2000 | PDF DocumentSpecialty : Epilepsy |
Category : Therapy
October 1999
- Weak evidence suggested that surgical decompression was effective for all levels of severity of ulnar nerve compression at the elbow (77-89%
chance of improvement).ID #30 | October 1999 | PDF DocumentSpecialty
: Neuromuscular | Category : Therapy
- With conservative management alone, 42% of mild cases of
ulnar neuropathies and 20% of severe cases became symptom free;79% improved and 21% worsened. Surgery was required in 21% of mild cases and 62% of severe cases, typically within 2 years.ID #29 | October 1999 | PDF DocumentSpecialty : Neuromuscular
| Categories : Prognosis, Therapy
April 1999
- Intramuscular injections
of gangliosides do not alter progressive deterioration of ALS.ID #19 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Categories : Prognosis, Therapy
- Overall, immune suppressants and modulating agents do not alter disease progression in ALS. Weak support for benefit with cyclosporine in early
stages of ALS.ID #20 | April 1999 | PDF DocumentSpecialty :
Neuromuscular | Categories : Prognosis, Therapy
- rhIGF-I may slow progression of functional impairment and the decline in health-related quality of life in ALS patients while
rhCNTF and TRH do not alter clinical progression of ALS.ID #24 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Categories : Prognosis, Therapy
- Riluzole appears to minimally improve survival in ALS. All other therapeutic trials of anti-glutamatergic and anti-excitotoxicity
agents reveal no significant effect.ID #23 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Category : Therapy
- The
NMJ "enhancers" physostigmine, neostigmine, and 3,4-DAP do not improve motor function in ALS.ID #17 | April 1999 | PDF
DocumentSpecialty : Neuromuscular | Category :
Therapy
- Ticlopidine may be
cost-effective in secondary stroke prevention in high-risk patients.ID #18 | April 1999 | PDF DocumentSpecialty : Vascular/Stroke | Category : Therapy
- Treatment of ALS with Modified Snake Venom did not alter clinical progression. Tilorone could actually cause harm.ID #22 | April
1999 | PDF DocumentSpecialty : Neuromuscular | Categories :
Harm, Prognosis, Therapy
- Treatment of ALS
with selegiline or L-Dopa does not alter the rate of clinical deterioration.ID #21 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Category : Therapy
January 1999
November 1998
- In cerebral edema following stroke, both mannitol and hypertonic saline may reduce raised intracranial pressure acutely.
Their effect on stroke outcome is not known.ID #13 | November 1998 | PDF DocumentSpecialties : Critical Care, Neurosurgery, Vascular/Stroke | Categories : Prognosis,
Therapy
- In patients with unusually severe headache, how useful is the clinical examination in determining whether an "inflammatory" CSF is
present?ID #12 | November 1998 | PDF DocumentSpecialties : Headache,
Neurological Exam | Category : Diagnosis
- Neuropathic pain responds better to tricyclic antidepressants (TCAs) than to SSRIs or placebo. The overall NNT for ³50% pain reduction is ~2.9 for
TCAs.ID #11 | November 1998 | PDF DocumentSpecialties :
Neuromuscular, Pain | Category : Therapy
August 1998
- There seems to be no significant difference among the new AED's effectiveness as add-on therapy for refractory partial seizures.ID
#9 | August 1998 | PDF DocumentSpecialty : Epilepsy | Category : Therapy
- In patients who have been seizure free for 2 years, slow withdrawal of anti-epileptic medication increases their risk of seizure recurrence by
at least 19% at 2 years.ID #5 | August 1998 | PDF DocumentSpecialty
: Epilepsy | Category : Prognosis
- In healthy adults with a first generalized seizure and normal
neurologic exam, the diagnostic yield (etiologically relevant) of outpatient investigations is: CT head=5%, EEG=60%, LABS=5%. With focal neurologic deficit the yield of brain imaging =
75%.ID #6 | August 1998 | PDF DocumentSpecialty : Epilepsy
| Categories : Diagnosis, Prognosis
- In highly selected patients, intravenous t-PA given within 3 hours of ischemic stroke onset improves outcome and mortality.ID #8 |
August 1998 | PDF DocumentSpecialty : Vascular/Stroke | Categories
: Prognosis, Therapy
- In patients with possible or probable MS, an MRI interpreted as "definitive MS" rules in the diagnosis.ID #7 | August
1998 | PDF DocumentSpecialty : Demyelinating Disease | Category
: Diagnosis
- IVIg is at least as effective and perhaps superior to Plasma Exchange in the treatment of patients with acute non-bulbar Guillain-Barre Syndrome.ID #4 | August 1998 | PDF DocumentSpecialty : Neuromuscular |
Category : Therapy
-
Richard S. McLachlan
MD, FRCPC
- Epilepsy
- View Dr. McLachlan's Bio...
-
Keith MacDougall
MD, FRCSC
- Epilepsy
- Pain / Neuro-oncology
- View Dr. MacDougall's Bio...
