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Diagnosis (29)
May 2005
Current evidence does not support aneurysm screening in first-degree relatives of patients with subarachnoid hemorrhage.ID
#119 | May 2005 | PDF DocumentSpecialty : Vascular/Stroke | Category : Diagnosis- In
suspected sporadic CJD, the diagnostic sensitivity and specificity of MRI was 67% and 93% respectively.ID #118 | May 2005 | PDF
DocumentSpecialty : Infection | Category :
Diagnosis
- There was an association between coffee consumption and the risk of developing Parkinson's disease.ID #120 | May 2005 |
PDF DocumentSpecialty : Movement Disorders | Category :
Diagnosis
August 1998
- In healthy adults with a first generalized seizure and normal
neurologic exam, the diagnostic yield (etiologically relevant) of outpatient investigations is: CT head=5%, EEG=60%, LABS=5%. With focal neurologic deficit the yield of brain imaging =
75%.ID #6 | August 1998 | PDF DocumentSpecialty : Epilepsy
| Categories : Diagnosis, Prognosis
- In patients with possible or probable MS, an MRI interpreted as "definitive MS" rules in the diagnosis.ID #7 | August
1998 | PDF DocumentSpecialty : Demyelinating Disease | Category
: Diagnosis
Economic Analysis (1)
Harm (4)
Meta-Analysis (1)
Prognosis (70)
January 2005
- Large size, posterior location, and prior history of SAH from another aneurysm was associated with an increased five-year rupture
rate of unruptured intracranial aneurysms.ID #113 | January 2005 | PDF DocumentSpecialty : Vascular/Stroke | Categories : Diagnosis, Prognosis
- Treatment of recurrent glioblastoma multiforme with temozolomide was safe and improved the proportion of patients with
progression-free survival at 6 months, as compared to procarbazine.ID #114 | January 2005 | PDF DocumentSpecialty : Oncology | Categories : Prognosis, Therapy
March 2002
- In patients with temporal-lobe epilepsy, surgery was superior to
prolonged medical therapy, at one-year follow-up. The NNT to render patients free from all seizures was 3 and free of seizures impairing awareness was 2.ID
#71 | March 2002 | PDF DocumentSpecialty : Epilepsy | Categories : Prognosis, Therapy
- Rivastigmine (6-12 mg daily) produced clinical and behavioral improvement in patients with Lewy-body dementia and was relatively well
tolerated.ID #70 | March 2002 | PDF DocumentSpecialty : Cognitive /
Behavioural | Categories : Prognosis, Therapy
October 2001
- Although generalized non-convulsive status epilepticus was associated with higher mortality in elderly, ICU
patients, the severity of the underlying illness predicted the outcome.ID #61 | October 2001 | PDF DocumentSpecialty : Epilepsy | Category : Prognosis
- In patients with GBS, the following factors predicted poor outcome: inability to walk
independently at 8 weeks, age > 50 years, preceding gastrointestinal illness, and MRC sum score <40.ID #62 | October 2001 | PDF
DocumentSpecialty : Vascular/Stroke | Category :
Prognosis
July 2001
- In cerebral sinus thrombosis, low molecular weight
heparin therapy for 3 weeks and 3 months of oral anticoagulation demonstrated a non-significant trend towards benefit over placebo. No significant hemorrhages occurred in those with preexisting
hemorrhage.ID #58 | July 2001 | PDF DocumentSpecialty :
Vascular/Stroke | Categories : Prognosis, Therapy
- In patients with anoxic encephalopathy, absent SSEPs, absent pupil reflexes, or no response to pain at 72
hours, independently predicted death or vegetative state with 100% specificity.ID #57 | July 2001 | PDF DocumentSpecialty : Critical Care | Categories : Diagnosis,
Prognosis
November 2000
- Donepezil (Aricept) slowed the progression of Alzheimer's disease up to one year, but the clinical significance is questionable.ID
#49 | November 2000 | PDF DocumentSpecialty : Cognitive / Behavioural |
Categories : Prognosis, Therapy
- The combination of dipyridamole and aspirin was more efficacious than aspirin alone in the secondary prevention of stroke.ID
#47 | November 2000 | PDF DocumentSpecialty : Vascular/Stroke | Categories : Prognosis, Therapy
April 1999
- Intramuscular injections of gangliosides do not alter progressive deterioration of ALS.ID #19 | April 1999 | PDF
DocumentSpecialty : Neuromuscular | Categories : Prognosis,
Therapy
- Overall, immune suppressants and modulating agents do not alter disease progression in ALS. Weak support for benefit with cyclosporine in early
stages of ALS.ID #20 | April 1999 | PDF DocumentSpecialty :
Neuromuscular | Categories : Prognosis, Therapy
- rhIGF-I may slow progression of functional impairment and the decline in health-related quality of life in
ALS patients while rhCNTF and TRH do not alter clinical progression of ALS.ID #24 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Categories : Prognosis,
Therapy
- Treatment of ALS with Modified Snake Venom did not alter clinical progression. Tilorone could actually cause harm.ID #22 | April
1999 | PDF DocumentSpecialty : Neuromuscular | Categories :
Harm, Prognosis, Therapy
August 1998
- In patients who have been seizure free for 2 years, slow withdrawal of anti-epileptic medication increases their
risk of seizure recurrence by at least 19% at 2 years.ID #5 | August 1998 | PDF DocumentSpecialty : Epilepsy | Category : Prognosis
- In healthy adults with a first
generalized seizure and normal neurologic exam, the diagnostic yield (etiologically relevant) of outpatient investigations is: CT head=5%, EEG=60%, LABS=5%. With focal neurologic deficit the yield of
brain imaging = 75%.ID #6 | August 1998 | PDF DocumentSpecialty :
Epilepsy | Categories : Diagnosis, Prognosis
- In highly selected patients, intravenous t-PA given within 3 hours of ischemic stroke onset improves outcome and mortality.ID #8 |
August 1998 | PDF DocumentSpecialty : Vascular/Stroke | Categories
: Prognosis, Therapy
Therapy (115)
July 2004
- In the short-term, IVIg treatment increased muscle strength and resulted in the subjective improvement of patients with multifocal motor
neuropathy.ID #105 | July 2004 | PDF DocumentSpecialty :
Neuromuscular | Category : Therapy
- Induced hypothermia reduced neurological disability and death when initiated early after VF cardiac arrest.ID #106
| July 2004 | PDF DocumentSpecialty : Critical Care | Categories : Prognosis, Therapy
April 2004
- At 3 months post-surgery, bilateral STN or GPi stimulation improved motor function in patients with advanced Parkinson's disease in the off
medication state.ID #103 | April 2004 | PDF DocumentSpecialty :
Movement Disorders | Category : Therapy
- In patients with atherothrombotic non-disabling stroke there was no reduction in
mortality, MI or stroke with the use of triple vitamin therapy; high dose folic acid, pyridoxine (B6), and cobalamin (B12).ID #102 | April 2004
| PDF DocumentSpecialty : Vascular/Stroke | Category :
Therapy
January 2004
- Bed rest was no better than immediate mobilization to prevent post-lumbar puncture headache.ID #100 | January 2004 |
PDF DocumentSpecialty : Other | Category :
Therapy
- IV dexamethasone decreased the risk of hearing loss in children with bacterial meningitis. The evidence was less convincing for
decreasing unfavourable outcomes in adults.ID #99 | January 2004 | PDF DocumentSpecialty : Infection | Categories : Prognosis, Therapy
- Canalith repositioning maneuvres shortened the duration of benign paroxysmal positional vertigo.ID #98 | January 2004 |
PDF DocumentSpecialty : Other | Category :
Therapy
June 2003
- Low quality evidence suggested that combined high-dose methotrexate and radiotherapy was the best treatment for primary CNS lymphoma.ID
#90 | June 2003 | PDF DocumentSpecialty : Oncology | Category : Therapy
- The evidence did not
support the use of HMG-CoA Reductase Inhibitors to prevent dementia.ID #91 | June 2003 | PDF DocumentSpecialty : Cognitive / Behavioural | Category : Therapy
April 2003
- All triptans were effective and well tolerated in
treatment of acute migraine. Compared with 100 mg sumatriptan, 12.5 mg rizatriptan and 80 mg eletriptan were slightly more efficacious; 12.5 mg almotriptan was similarly efficacious but better
tolerated.ID #88 | April 2003 | PDF DocumentSpecialty :
Headache | Category : Therapy
- Carbamazepine was effective in the short-term management of trigeminal neuralgia (NNT 2.6 vs.
placebo). No drugs have demonstrated superiority in monotherapy. Surgery has not been adequately evaluated.ID #89 | April 2003 | PDF
DocumentSpecialty : Headache | Category :
Therapy
February 2003
- Acyclovir was superior to Vidarabine in the treatment of biopsy-proven HSV encephalitis.ID #86 | February 2003 | PDF
DocumentSpecialty : Infection | Category :
Therapy
- Interferons decreased the risk of exacerbations in Relapsing-Remitting Multiple
Sclerosis for 2 years. Differing efficacy between various preparations and administration protocols is questionable.ID #85 | February 2003
| PDF DocumentSpecialty : Demyelinating Disease | Categories :
Prognosis, Therapy
January 2003
- Mitoxantrone 12mg/m^2 may reduce progression of disability in SP MS. However, clinical significance is questionable.ID
#83 | January 2003 | PDF DocumentSpecialty : Demyelinating Disease | Categories : Prognosis, Therapy
- Weak evidence showed improved survival with the use of BiPAP in patients with respiratory insufficiency due to ALS.ID #84 | January
2003 | PDF DocumentSpecialty : Neuromuscular | Category :
Therapy
March 2002
- In patients with temporal-lobe epilepsy, surgery was superior to
prolonged medical therapy, at one-year follow-up. The NNT to render patients free from all seizures was 3 and free of seizures impairing awareness was 2.ID
#71 | March 2002 | PDF DocumentSpecialty : Epilepsy | Categories : Prognosis, Therapy
- Rivastigmine (6-12 mg daily) produced clinical and behavioral improvement in patients with Lewy-body dementia and was relatively well
tolerated.ID #70 | March 2002 | PDF DocumentSpecialty : Cognitive /
Behavioural | Categories : Prognosis, Therapy
February 2002
- Clopidogrel plus aspirin therapy for acute coronary
syndromes without ST-elevation modestly reduced the risk of myocardial infarction (NNT 40) and the composite outcome of cardiovascular death, non-fatal MI, stroke OR refractory ischemia (NNT
43).ID #68 | February 2002 | PDF DocumentSpecialties : Other,
Vascular/Stroke | Categories : Prognosis, Therapy
- Depressed elderly outpatients and inpatients improved in depression scores by treating with TCA's (NNT 4), and SSRI's (NNT 8).ID
#69 | February 2002 | PDF DocumentSpecialty : Other | Category : Therapy
November 2001
- Diagnostic testing for coagulopathies had a low yield in patients with ischemic stroke, except for Antiphospholipid Antibodies.ID
#65 | November 2001 | PDF DocumentSpecialty : Neuromuscular | Categories : Economic Analysis, Meta-Analysis, Therapy
- Vagus nerve stimulation was moderately effective in reducing medically refractory partial seizures in the short term.ID
#64 | November 2001 | PDF DocumentSpecialty : Epilepsy | Category : Therapy
February 2001
- Early interferon treatment delayed
development of a second neurological event (ie. clinically definite multiple sclerosis) in patients with one demyelinating neurological event and MRI lesions indicative of previous clinically silent
demyelinating events.ID #53 | February 2001 | PDF DocumentSpecialty
: Demyelinating Disease | Categories : Prognosis, Therapy
- Gabapentin may be helpful in the treatment of
essential tremor.ID #51 | February 2001 | PDF DocumentSpecialty :
Movement Disorders | Category : Therapy
- No valid evidence to
support any treatment for idiopathic intracranial hypertension.ID #52 | February 2001 | PDF DocumentSpecialties : Headache, Other | Category : Therapy
November 2000
- Donepezil (Aricept) slowed the progression of Alzheimer's disease up to one year, but the clinical significance is questionable.ID
#49 | November 2000 | PDF DocumentSpecialty : Cognitive / Behavioural |
Categories : Prognosis, Therapy
- The combination of dipyridamole and aspirin was more efficacious than aspirin alone in the secondary prevention of stroke.ID
#47 | November 2000 | PDF DocumentSpecialty : Vascular/Stroke | Categories : Prognosis, Therapy
- The utilization of a graduated compression device (TED stockings) in addition to another prophylactic method prevented DVTs.ID #48
| November 2000 | PDF DocumentSpecialty : Other | Category
: Therapy
October 1999
- Weak evidence suggested that surgical decompression was effective for all levels of severity of ulnar nerve compression at
the elbow (77-89% chance of improvement).ID #30 | October 1999 | PDF DocumentSpecialty : Neuromuscular | Category : Therapy
- With conservative management alone, 42% of
mild cases of ulnar neuropathies and 20% of severe cases became symptom free;79% improved and 21% worsened. Surgery was required in 21% of mild cases and 62% of severe cases, typically within 2
years.ID #29 | October 1999 | PDF DocumentSpecialty :
Neuromuscular | Categories : Prognosis, Therapy
April 1999
- Intramuscular injections of gangliosides do not alter progressive deterioration of ALS.ID #19 | April 1999 | PDF
DocumentSpecialty : Neuromuscular | Categories : Prognosis,
Therapy
- Overall, immune suppressants and modulating agents do not alter disease progression in ALS. Weak support for benefit with cyclosporine in early
stages of ALS.ID #20 | April 1999 | PDF DocumentSpecialty :
Neuromuscular | Categories : Prognosis, Therapy
- rhIGF-I may slow progression of functional impairment and the decline in health-related quality of life in
ALS patients while rhCNTF and TRH do not alter clinical progression of ALS.ID #24 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Categories : Prognosis,
Therapy
- Riluzole appears to minimally improve survival in ALS. All other therapeutic trials of anti-glutamatergic and anti-excitotoxicity
agents reveal no significant effect.ID #23 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Category : Therapy
- The
NMJ "enhancers" physostigmine, neostigmine, and 3,4-DAP do not improve motor function in ALS.ID #17 | April 1999 | PDF
DocumentSpecialty : Neuromuscular | Category :
Therapy
- Ticlopidine may be
cost-effective in secondary stroke prevention in high-risk patients.ID #18 | April 1999 | PDF DocumentSpecialty : Vascular/Stroke | Category : Therapy
- Treatment of ALS with Modified Snake Venom did not alter clinical progression. Tilorone could actually cause harm.ID #22 | April
1999 | PDF DocumentSpecialty : Neuromuscular | Categories :
Harm, Prognosis, Therapy
- Treatment of ALS
with selegiline or L-Dopa does not alter the rate of clinical deterioration.ID #21 | April 1999 | PDF DocumentSpecialty : Neuromuscular | Category : Therapy
January 1999
November 1998
- In cerebral edema following stroke, both mannitol and hypertonic saline may reduce raised intracranial pressure acutely.
Their effect on stroke outcome is not known.ID #13 | November 1998 | PDF DocumentSpecialties : Critical Care, Neurosurgery, Vascular/Stroke | Categories : Prognosis,
Therapy
- Neuropathic pain responds better to tricyclic antidepressants (TCAs) than to SSRIs or placebo. The overall NNT for ³50% pain reduction is ~2.9 for
TCAs.ID #11 | November 1998 | PDF DocumentSpecialties :
Neuromuscular, Pain | Category : Therapy
August 1998
- There seems to be no significant difference among the new AED's effectiveness as add-on therapy for refractory partial seizures.ID
#9 | August 1998 | PDF DocumentSpecialty : Epilepsy | Category : Therapy
- In highly selected patients, intravenous t-PA given within 3 hours of ischemic stroke onset improves outcome and mortality.ID #8 |
August 1998 | PDF DocumentSpecialty : Vascular/Stroke | Categories
: Prognosis, Therapy
- IVIg is at least as effective and perhaps superior to Plasma Exchange in the treatment of patients with acute non-bulbar Guillain-Barre
Syndrome.ID #4 | August 1998 | PDF DocumentSpecialty :
Neuromuscular | Category : Therapy
-
J. David Spence
B.A., M.B.A., M.D., FRCPC, FAHA, FCAHS
- Cerebrovascular
- View Dr. Spence's Bio...
-
Mel Boulton
MD, PhD, FRCSC
- Cerebrovascular
- View Dr. Boulton's Bio...
